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VOLTAGE-GATED SODIUM CHANNELS
Descriptors Found:
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DeCS
Descriptor
English
:
Voltage-Gated Sodium Channels
Descriptor
Spanish
:
Canales de Sodio Activados por Voltaje
Descriptor
Portuguese
:
Canais de Sódio Disparados por Voltagem
Synonyms
English
:
Channels, Voltage-Gated Sodium
Sodium Channels, Voltage Gated
Sodium Channels, Voltage-Gated
Voltage Gated Sodium Channels
Tree Number:
D12.776.157.530.400.875.750
D12.776.543.550.450.875.750
D12.776.543.585.400.875.750
D12.776.631.960
Definition
English
:
A
family
of
membrane proteins
that selectively conduct
SODIUM
ions due to changes in the TRANSMEMBRANE POTENTIAL DIFFERENCE. They typically have a multimeric structure with a core alpha subunit that defines the
sodium
channel subtype and several beta subunits that modulate
sodium
channel activity.
Indexing Annotation
English
:
general or unspecified; prefer specifics
Entry Combination - descr/qualif
English
:
Voltage-Gated Sodium Channels
/
antagonists & inhibitors
use
Voltage-Gated Sodium Channel Blockers
Voltage-Gated Sodium Channels
/
agonists
use
Voltage-Gated Sodium Channel Agonists
History Note
English
:
2013
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
54946
Unique Identifier:
D061566
Occurrence in VHL
:
Similar:
DeCS